The Division of Hematology and UCHealth held another successful Denver ASH Review on February 6, 2021. While the COVID-19 pandemic kept colleagues from meeting in person, the benefit of having the event in a virtual format was the ability of presenters and participants from across the nation to join the conference. Two hundred and twenty participants tuned in to hear five leaders in the field of hematology and oncology share their expertise and updates about myeloproliferative neoplasms, lymphomas, acute myeloid leukemia, CAR-T cell therapy, and multiple myeloma from the 62nd Annual American Society of Hematology Annual Meeting and Exposition in December 2020.
Dr. Steven Bair from the University of Colorado provided a thorough update on the treatment of lymphomas. Dr. Bair states, “The field is rapidly evolving. This was reflected by the abstracts presented at ASH which suggest a paradigm shift” in the way lymphoma is treated. “We are moving toward combination regimens in first-line treatment, development of next-generation drugs such as BTK inhibitors, and time-limited approaches to therapy.”
Dr. Ruben Mesa from the Mays Cancer Center at UTHealth San Antonio gave an insightful overview of myeloproliferative neoplasms and the updates affecting medical management and survival. Dr. Mesa states, “MPNs are chronic conditions,” and it is important to understand “the holistic sense of MPN disease burden” as symptoms inform us about MPN biology. Dr. Mesa also discussed the expanding treatment options for essential MPNs including interferon, hepcidin mimetic PTG-300, and JAK inhibition. Dr. Mesa states, “various myelofibrosis approaches in the pipeline may impact first-line treatment, second-line treatment, and how we use transplant.”
Dr. Joseph Mikhael, from Honor Health in Scottsdale AZ, provides an exciting presentation on the current landscape of myeloma research by providing a great review of the progress of survival in myeloma and the many new molecules available to treat this disease. Several key abstracts from ASH 2020 are discussed along with their significance in clinical practice. The main areas discussed are frontline therapy, the role of autologous stem cell transplant, early relapse, CAR-T cell therapy, and bispecific therapy. Furthermore, Dr. Mikhael discusses other drugs that may affect the landscape of myelomas, such as Iberdomide (Cell Mod) and Melphalan Flufenamide (Melflufen). His overview is very effectively wrapped up by summaries on the pillars, options, and evolution of myeloma therapy.
Dr. Christine McMahon, from the University of Colorado, reviews some of the exciting and clinically relevant ASH presentations on MDS and AML. Special attention is set to research involving Pevonedistat, Imetelstat, and Venetoclax, whose role continues to evolve within the treatment spectrum of AML. Dr. McMahon also covers research that has to lead to the identification of poor treatment outcomes in young patients with AML within the African American population. Furthermore, treatment of AML via molecularly targeted therapies, such as Enasidenib and Gilteritinib, as well as new agents to treat AML, such as Magrolimab, Flotetuzumab, and SY-1425 are also discussed.
Dr. Elizabeth Budde, from the City of Hope in Duarte CA, provides an in-depth overview of the current CAR-T cell therapies in hematologic malignancies. Her review on lymphoma covers the use of Axi-Cel for long-term disease control in pts w/ refractory LBCL, the response rate and safety profile of CAR-T treatment in iNHL, and the use of CAR-T in front line therapy for aggressive B-cell lymphoma. Also discussed are the testing of early delivery, high potency, and reduced toxicity of new CAR-T cell therapies, as well as a great discussion regarding CAR-T clinical development in AML. Dr. Budde closes by reviewing the exciting year that multiple myeloma research has presented by going over the novel CAR-T cell design and off-the-shelf allogeneic anti-BCMA CAR design. The FDA priority review of Ide-cel and Cilta-Cel are also discussed. Give customers a reason to do business with you.
Division of Hematology CE presentations are strictly for educational purposes only. Our main goal is to increase the knowledge and competence of those within the medical field to improve patient care. Presenters will not provide direct medical, consultation, diagnostic, or treatment advice to participants.